Öz
Doğrudan etkili antiviraller, kronik hepatit C virüsü (HCV) enfeksiyonunun tedavisinde yüksek kalıcı virolojik yanıt (SVR) oranlarına ulaşılmasını sağlamıştır. Ancak glekaprevir/pibrentasvir (G/P) tedavisinin başarısızlığı sonrasında yeniden tedavi stratejilerine ilişkin veriler sınırlı kalmaktadır. Bu yazıda, genotip 3 kronik HCV enfeksiyonu olan ve 8 haftalık G/P rejimine tam uyum göstermesine rağmen virolojik başarısızlık gelişen 48 yaşındaki bir erkek olgu sunulmaktadır. Hasta daha sonra 12 hafta süreyle sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) ile tedavi edilmiş olup, tedavi sonunda ve tedavi bitiminden 12 hafta sonra karaciğer enzim düzeylerinin normalleştiği ve HCV ribonükleik asidinin saptanamaz olduğu gösterilerek SVR12 elde edildiği doğrulanmıştır. Bu olgu, önceki G/P tedavisinde başarısızlık gelişen genotip 3 HCV enfeksiyonlu hastalarda SOF/VEL/VOX’un etkili ve güvenli bir kurtarma tedavisi seçeneği olabileceğini göstermekte ve yeniden tedavi kararlarına klinik açıdan yol gösterici nitelik taşımaktadır.
Anahtar Kelimeler:
Kronik viral hepatit C, doğrudan etkili antiviraller, hepatit C
Kaynaklar
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